Search
Now showing items 1-10 of 11
Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients
(2003-09-05)
The age-adjusted incidence rate of non-Hodgkin´s lymphoma (NHL), in particular diffuse large B cell lymphoma, has increased continuously during several decades. Patients with aggressive NHL are potentially curable but the ...
Novel skeletal stem and progenitor cells and their regulation
(2022-01-20)
The development of bone and cartilage, which provide the framework of the skeletal system,
is complex. In this context stem and progenitor cells play a crucial role by producing
differentiated cells. Hormones are important ...
Structural maintenance of chromsomes : a complex tale of genomic integrity
(2009-04-03)
Genomic integrity is an absolute requirement for cell survival.
Programmed events such as genome rearrangements and DNA replication can
cause lesions in the DNA, as can exogenous agents such as radiation and
chemicals. ...
Peripheral nerve glia as multipotent progenitors in craniofacial development
(2014-12-22)
Craniofacial development is complex. Numerous populations of progenitor cells coordinate
activities to produce an array of highly integrated tissues inside the developing head.
However, it is not clear how some key ...
DNA repair by HDR in experimental tumorigenesis
(2008-05-15)
The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members ...
CADASIL : a pure model for studying cerebral small vessel disease
(2019-05-23)
Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is caused by a mutation on the NOTCH3 gene. The pathological driver behind this disease is the loss of vascular smooth ...
Ready to pull : force transmission during vascular development
(2019-12-17)
The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ...
Diagnostic precision and sex differences in quantitative cardiovascular magnetic resonance
(2018-03-22)
Correct medical treatment necessitates a correct diagnosis. Cardiac imaging aims to establish an accurate diagnosis without performing unnecessary invasive procedures. Cardiovascular magnetic resonance (CMR) has emerged ...
Pathological responses of glial cells in spinal cord injury and rheumatoid arthritis
(2017-11-02)
Scientists have considered glia as mere passive allies of neurons for a long time. As a consequence, their functions have been greatly underestimated. Major discoveries made in the last three decades have changed our view ...
DNA topoisomerases and nucleosome dynamics in fission yeast
(2015-05-12)
The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, ...