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Surgical treatment of atrial fibrillation : clinical, hormonal and electrophysiological aspects of the maze operation
(2003-01-17)
Background: Atrial fibrillation (AF) is the most common arrhythmia, associated with significant mortality and morbidity, due to hemodynamic impairment and the increased risk of stroke. Traditional pharmacological treatment ...
A community-based child drowning prevention program in Bangladesh : a model for low income countries
(2010-11-25)
Background: Drowning is a global public health problem of children. Children of low- and
middle-income countries are the most susceptible victims. Prevention measures implemented in
high-income countries have effectively ...
Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection
(2016-08-29)
Microbial translocation and increased immune activation have been involved in functional T cell impairments and disease progression during HIV-1 infection. The impact of microbial translocation on the phenotype of memory ...
Science and practice of balanced scorecard in a hospital in Pakistan : feasibility, context, design and implementation
(2010-03-03)
Background: Millennium Goals emphasize good governance and health systems
research. In Pakistan, hospitals provide the major bulk of both basic and
advanced care. Challenges faced by the hospitals in Pakistan include:
poor ...
Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific B cell responses
(2019-11-21)
Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most ...
Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses
(2018-06-04)
In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited antibodies ...
Approaches to modulate vaccine-induced antibody responses
(2017-09-15)
Most successful licensed vaccines mediate protection by inducing antibody responses capable of protecting the individual from infection or disease. Despite the availability of many effective vaccines, we lack knowledge ...
Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15
(2016-10-28)
Synthetic nucleobase- and nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against various forms of cancer. Due to their resemblance to endogenous nucleotides these antimetabolites ...
Shoulder injuries in adolescent elite handball players
(2019-10-04)
Background: Handball is a physically demanding sport that includes jumping, running, side-cutting movements and frequent throwing. A high prevalence of shoulder problems and pain has been reported in adult handball players ...