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Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism
(2002-11-15)
CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of ...
Ductal adenocarcinoma of the prostate : a morphological, immunohistochemical and genetic study
(2016-11-16)
Ductal adenocarcinoma of the prostate (DAC) is the second most common prostate cancer subtype. Patients with DAC often present at an advanced clinicopathological stage, with or without metastases. Patients have a high rate ...
On the roles of genes in Parkinson's disease
(2008-05-21)
Parkinson’s disease is a progressive neurodegenerative disorder which affects 1% of the population over the age of 60. In order to identify candidate genes with a potential role in Parkinson’s disease pathology, we ...
Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
A fibrinogen-binding protein from Staphylococcus epidermidis
(2001-11-09)
Staphylococcus epidermidis, a coagulase negative staphylococci (CoNS), is a major component of human flora. It is one of the leading pathogens of nosocomial infections, particularly associated with foreign body infections. ...
Therapeutic applications of acoustic and electromagnetic energy
(2005-02-10)
This thesis focuses on techniques based on electromagnetic and acoustic energy for treatment of a variety of diseases, including development of new techniques as well as improvement and evaluation of existing techniques. ...
Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies
(2013-09-11)
The infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently ...
Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation
(2008-03-21)
The homeostasis of intracellular redox status has a crucial role in the
cell survival and different processes such as DNA synthesis, gene
expression, enzymatic activity, etc. This homeostasis is achieved via an
intense ...
Parental exposures and occurence of adverse pregnancy outcomes and childhood atopic diseases
(2006-03-17)
The aim of this thesis was to investigate whether parental laboratory work is associated with adverse pregnancy outcomes, and if maternal occupation as well as exposure to organic solvents and smoking during pregnancy are ...
Stem cell transplantation : home care, graft-versus-host disease and costs
(2006-01-20)
Allogeneic stem-cell transplantation (ASCT) is used to treat malignant and non-malignant diseases of the immunohematopoietic system. Results in terms of survival rate and less complications are continually improving due ...