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Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
Rheumatoid arthritis (RA) is a disabling chronic inflammatory disease, presumably autoimmune, that progressively destroys peripheral joints. The etiopathogenesis remains largely unknown, and an understanding of disease ...
Feeding the very low birth weight infant : short and long term effects of tube feeding methods in early postnatal life
(2012-05-25)
The overall aim of this thesis was to investigate short term effects of enteral feeding methods, continuous versus intermittent bolus feeding in very low birth weight infants on gastro intestinal tolerance and growth (I) ...
Movement awareness and communication in patient transfer : an educational intervention
(2009-08-14)
Background: This thesis addresses patient transfer, i.e., assisting the physical movement of patients with disabilities. Patient transfer is the primary cause of work-related disorders in healthcare providers. It has mainly ...
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
(2016-10-05)
To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect ...
Malaria and polypeptides of Plasmodium falciparum at the infected erythrocyte surface
(2016-03-11)
Malaria is one of the top three most lethal infectious diseases in the world after tuberculosis
and HIV. The disease is caused by intracellular parasites of the genus Plasmodium spp. To
date, five Plasmodium spp have ...
Antimicrobial polypeptides and lipids as a part of innate defense mechanism of fish and human fetus
(2005-11-18)
Animals are constantly threatened by vast numbers of microbes and have
consequently evolved an array of strategies to prevent microbial
invasion. In this thesis, I have studied natural antimicrobial lipids and
polypeptides ...
The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins
(2010-05-07)
Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the
brain that eventually results in cognitive decline. Characteristic
hallmarks of AD are senile plaques containing the amyloid beta-peptide
(Abeta) ...
Crimean-Congo hemorrhagic fever virus : interactions with host cell structures in viral replication
(2008-10-02)
Crimean-Congo hemorrhagic fever virus (CCHFV) is a human pathogen, and
was first associated with its corresponding disease during an outbreak in
the mid 1940s. At that time, outbreaks were mainly restricted to the
former ...
Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease
(2013-08-14)
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions. Mechanisms that stimulate, manage and regulate ...
Drug discovery targeting non-amyloid pathways in Alzheimer’s disease
(2020-04-02)
Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an ...