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Blood saving in orthopaedic surgery
(2002-05-10)
A substantial blood loss frequently accompanies total hip and knee replacement surgery. This is a potential health risk and associated with increased need for allogenic blood transfusions. Blood transfusions in turn may ...
Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity
(2019-05-28)
SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles ...
Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
Molecular genetic studies on cerebrospinal fluid monoamine metabolites in psychotic patients and healthy individuals
(2015-02-26)
Dopamine, serotonin and noradrenaline are the major monoamines in the human central nervous system (CNS) and following their basic pathways they are degraded to their major metabolites homovanillic acid (HVA), 5-hydroxyi ...
Evaluation of carbon dioxide insufflation into the open surgical wound : influence on wound temperature, core temperature, and postoperative outcome
(2016-01-22)
Introduction: When the internal organ tissues are abruptly exposed to the relative cold and dry ambient air during open surgery, body heat is lost through radiation, evaporation, and convection. Also general and neuraxial ...
On the assessment of nerve involvement and of dysfunction in patients with spinal pain
(2009-01-23)
Nerve involvement originating in the spine can cause pain and/or organ dysfunction. Reliable and valid assessment of nerve involvement is a prime diagnostic task as it may require other than symptomatic treatment.
The ...
Tissue prostatic specific antigen (T-PSA) : a way to predict and understand the development of prostate cancer
(2001-09-21)
Prostate cancer (CaP) is the most prevalent malignancy among men in
Sweden. One major problem associated with CaP is the choice of treatment
since the disease may develop very differently from patient to patient.
Many ...
Exosomes in immune regulation and allergy
(2007-04-20)
Exosomes are nano-sized vesicles of endosomal origin which are secreted from several different cell types. Depending on their cellular source they have been suggested to have different functions, like having a role in ...
Various aspects of treatment in cardiac arrest prior to hospital arrival
(2014-04-04)
Background and aims: Out-of-hospital cardiac arrest (OHCA) is a major public health issue, affecting almost 300,000 victims per year in Europe, who have an overall survival rate of about 10 per cent. In general, the current ...
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models
(2016-05-20)
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination ...