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Pharmacokinetic and pharmacodynamic aspects on opioid administration, morphine and ketobemidone, in the pediatric population
(2012-10-23)
Opioids are the mainstay of the treatment of severe nociceptive pain in both children and adults. The studies in this thesis have focused on different aspects of opioid treatment in the pediatric population with special ...
Genetics of androgen disposition : implications for doping tests
(2007-11-02)
Anabolic androgenic steroids (AAS) are derivatives of testosterone.
Doping with AAS is a severe challenge to the vision, moral and ethics in
sports and has also become an increasing problem in society.
Testosterone ...
Functional and genetic studies in type 2 diabetes and obesity
(2013-11-14)
Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and ...
PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry
(2020-11-27)
Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments ...
Register-based studies of sex steroid hormones and psychiatric disorders
(2023-01-27)
The focus of this thesis is the interplay between sex steroid hormones, psychiatric- and
neurodevelopmental disorders and adverse behavioral outcomes. Sex steroid hormones
are mostly known for their role in sexual ...