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A genetic study on familial breast cancer predisposing genes
(2002-05-02)
Breast cancer is the most common malignant disease among women in the western world and 10% of all breast cancer is assumed to constitute hereditary cases. Two major genes, BRCA1 and BRCA2, can only explain a fraction of ...
Involvement of mitogen-activated protein kinases in mast cell mediator induced airway hyper-responsiveness in guinea pig trachea
(2016-12-13)
Introduction: Exposure to allergens causes activation of mast cells and release of its mediators leading to airway constriction. Airway hyper-responsiveness (AHR) is a major characteristic of asthma but understanding of ...
Human iPSC derived neural cells as models of brain development and as tools in pharmaceutical drug discovery
(2018-12-12)
Human brain evolution has resulted in a cognitive superiority compared to all other animals. Unique cortical structures and expanding progenitor populations have been associated with the possibility for developing a highly ...