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Interoception as independent cardiac, thermosensory, nociceptive, and affective touch perceptual submodalities
(Elsevier, 2022-09-08)
Interoception includes signals from inner organs and thin afferents in the skin, providing information about the body’s physiological state. However, the functional relationships between interoceptive submodalities are ...
Immune mechanisms in atherosclerosis
(2001-02-23)
Atherosclerosis is a multifactorial chronic inflammatory disorder. Humoral immune factors as anticardiolipin antibodies (aCL), anti-oxLDL antibodies, circulating immune complexes (CICs), and proinflammatory cytokines such ...
Characterization of F-box proteins and their target substrates in cancer
(2014-11-11)
Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...
The many faces of IGF-1R from cell surface to the nucleus
(2009-05-01)
The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. ...
Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
(2018-09-21)
Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current ...
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
(2014-05-19)
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance ...
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(2007-10-05)
The growth hormone (GH) / insulin-like growth factor (IGF) family of
ligands, binding proteins and receptors play multiple roles in cell
growth, metabolism and development. In addition, numerous studies have
demonstrated ...
Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein
(2004-03-26)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
causes the most common form of dementia. Pathological lesions, such as
plaques consisting of the amyloid beta-peptide (Ab), are found in the
brains ...
Identification and characterization of a proteasome deubiquitinase inhibitor
(2014-01-10)
The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of ...