Search
Now showing items 1-10 of 14
Studies on oral clearance of citric acid and its effect on enamel erosion
(1996-05-10)
Citric acid in foods is one of the most important factors causing erosionof enamel. The aims were to study citric acid clearance from the oral cavity, the effect of the clearance on the salivary saturation with respect to ...
On the mechanisms and consequences of cell to cell DNA transfer
(2007-11-23)
Development of cancer is a multistep process where an accumulation of
genetic alterations drives normal cells to malignancy. In most cancer
cells genetic changes can be observed both at the level of point
mutations and as ...
Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities
(2008-02-22)
Radiation therapy is used in attempting to kill tumor cells by inducing DNA double- strand breaks (DSB), the most critical DNA lesions. Recent and planned radiation therapy strategies use high-linear energy transfer (LET) ...
Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites
(2018-05-25)
Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result in ...
Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle
(2016-05-27)
The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. Successful execution ...
Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma
(2009-05-21)
Epidemiological and molecular evidence link Epstein-Barr virus (EBV)
infection to a variety of lymphoid and epithelial malignancies but the
contribution of the virus to tumorigenesis is unclear. Genomic
instability, ...
Unwrapping the role of WRAP53β in DNA damage response
(2016-04-29)
WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal ...
Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling
(2015-09-22)
Cancer is, despite rapid progress in development of new targeted therapies, still mainly
treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned
conventional therapies often meet general ...
Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance
(2003-05-02)
In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for ...
Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target
(2008-05-23)
In this thesis powerful proteomics methods were used to reveal novel proteins involved in the cellular response to DNA damaging treatment. The goal was to find proteins with potential as biomarkers for prediction of cancer ...