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5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP
(2000-09-13)
Human 5-lipoxygenase (5LO) is a monomeric non-heme iron enzyme, which catalyses the first two steps in the biosynthesis of leukotrienes: oxygenation of arachidonic acid to yield 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicos ...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
Proteomics in neurological disease
(2009-11-06)
Neurodegenerative and neuroinflammatory diseases are conditions affecting the central nervous system that in the end have dramatic impacts on the affected individuals and their families. Today, large efforts are made to ...
Interferon-beta treatment in multiple sclerosis : analysis of neutralizing antibodies
(2008-09-05)
Multiple sclerosis (MS) is a disabling chronic neurological disease with
a significant impact on patients lives. There is no cure for MS, but
recombinant interferon beta (IFN-beta) is currently the most established
disease ...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and ...
Sex and gender aspects in drug utilization
(2021-03-04)
Drug prescribing is one of the most important processes in healthcare and drugs are also commonly used in the population. Drug use differs between men and women and descriptive reports of sex differences in drug use have ...