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Prostate cancer diagnostics : complications and ways to reduce unnecessary biopsies
(2014-12-29)
Introduction: Prostate cancer is the most common form of cancer among men in Sweden.
There has been a rapid increase in the incidence rate of prostate cancer following the
introduction of PSA testing and, today, more ...
Scarring and regeneration in the central nervous system
(2021-11-12)
In response to injury, tissues employ conserved reparative mechanisms to heal the damage and recover their function. The reparative success varies according to the organism, the tissue or organ, and the age of the specimen. ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease. To accomplish this cells rely on DNA ...
The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci
(2003-03-07)
In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma ...
Regulation of molecular processes in diffuse large B-cell lymphoma
(2013-04-25)
The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and ...
Mediators of synaptic activity in anxiety- and depression-related behaviors
(2012-05-16)
Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously ...
Register-based studies on childhood cancer : relapsed childhood acute lymphoblastic leukemia and skeletal adverse events in childhood cancer survivors in the Nordic countries
(2022-01-28)
Background: Although cancer is a rare disease in children, it is the leading disease-related cause of death in children and adolescents in developed countries. Currently 80% of patients become long-time survivors but if a ...
Orofacial aspects of juvenile idiopathic arthritis in children
(2023-04-04)
Aims: This thesis, which investigates orofacial aspects and temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA), aims to improve knowledge about the variables to include in a clinical examination, ...