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Congenital heart block : a study of diagnostics, pathogenesis, prognosis and treatment
(2014-05-15)
Congenital heart block (CHB) is a rare condition with considerable mortality. In most patients the disease is associated with fetal exposure to maternal SSA-Ro and/or SSB-La autoantibodies (AB) and develops in fetal life. ...
Using enriched quality register data for health care evaluation : examples from rheumatoid arthritis
(2014-09-24)
Swedish registers have for decades successfully been used for medica research, enabling long-term follow-up of large patient cohorts using observational designs. With a tax funded health care system and the use of a personal ...
In situ characterization of immune cells mediating potential control of HIV infection in the female genital mucosa
(2016-04-01)
Heterosexual HIV transmission is the most common viral transmission route, worldwide,
where young women are more susceptible to HIV infection than men. To establish a
persistent infection the virus needs to cross the ...
Beyond transcription : a post-transcriptional role of 3D chromatin crosstalk in oncogene regulation
(2022-09-09)
This thesis explores how stochastic chromatin fibre interactions, chromatin organization in the 3D nuclear architecture, and environmental signals collaborate to regulate MYC oncogene expression in human colon cancer cells. ...