Search
Now showing items 1-10 of 28
Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia
(2003-12-26)
The investigation of minimal residual disease (MRD) with multiparameter flow cytometry (FC) immunophenotyping has proven to be a powerful approach for disease monitoring in patients with acute leukemia (AL). This technique ...
Socioeconomic differences in drug use among older people : trends, polypharmacy, quality and new drugs
(2008-09-09)
Polypharmacy and potentially inappropriate drug use (IDU) is a major
patient safety and public health concern in the elderly, resulting in an
increased likelihood of adverse drug reactions, drug-drug interactions
(DDI), ...
Deciphering the transcriptional regulation code in colorectal cancer genome
(2014-03-06)
Colorectal cancer (CRC) is the third most common cancer type to threaten life for both men and women in the developed world. The molecular mechanism of CRC is very complicated and involves changes in different categories ...
Exploring the genomic and transcriptomic landscape of immune cells in multiple sclerosis : towards better biomarkers, diagnosis and treatment
(2020-02-07)
The overall aim of this thesis was to determine the changes in gene regulation taking place in immune cells during the course of Multiple Sclerosis. Over 200 MS-associated SNPs have been identified from GWAS studies. These ...
X-chromosome upregulation is driven by increased burst frequency
(2020-05-12)
Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
Experimental studies on novel pharmacological strategies in the treatment of schizophrenia
(2006-05-19)
The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state ...
Brain opioid mechanisms in amphetamine induced behaviours
(2009-09-04)
Amphetamine abuse and dependence are global health problems, affecting large numbers of individuals. Despite extensive research efforts, there has been no evidence-based pharmacotherapy available for amphetamine dependence. ...
Epidemiological studies on breast cancer risk factors and screening
(2023-09-27)
This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...
Breast cancer survivors : information needs, attitudes towards illness and quality of life
(2010-03-26)
Breast cancer (BC) is the most common female cancer. Only in Sweden about
7300 women are affected each year and 1500 die from the disease.
Following progress in early detection and therapy there has been a marked
improvement ...