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Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
(Springer Nature, 2022-12-06)
Extracellular vesicles (EVs) can be functionalized to display specific protein receptors on their surface. However, surface-display technology typically labels only a small fraction of the EV population. Here, we show that ...
3D imaging and quantitative analysis of intact tissues and organs
(2020-04-17)
Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ...
Engineered extracellular vesicles for biomedical applications
(2021-12-28)
Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The ...
The role of human cytomegalovirus infection in cancer
(2013-05-20)
Cancer is a major cause of morbidity and mortality worldwide. It is thought that up to 20% of cancers are caused by infectious agents, and an oncogenic role of several viruses has been established for certain tumours. ...
Novel molecular techniques for diagnostics and cancer biology
(2022-11-25)
Molecular biology is reliant on a large set of increasingly complex methods. The development of high-throughput DNA sequencing almost 20 years ago kicked off a revolution in method development due to its incredible ...
Modelling and genetic correction of liver genetic diseases
(2021-03-24)
The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being ...
A modular mRNA approach to study and treat phospholamban mediated cardiomyopathies
(2022-05-30)
In the heart, phospholamban (PLN) is a key regulator of calcium cycling through its inhibitory effect on the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. For more than two decades, modulating calcium channels has ...
Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer
(2022-09-19)
Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR ...
Genetic and functional analysis of the adaptive immune response
(2023-02-01)
The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta ...
Exploring the interaction between the human microbiota and infections
(2022-10-26)
The microbiota is a living ecosystem that is influenced by a variety of host and environmental factors. Distinct microbiota colonizes various body sites, such as the gastrointestinal system and vaginal tract, corresponding ...