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Clinical grade vitrification of human ovarian tissue for fertility preservation
(2013-05-16)
Cryopreservation of human ovarian tissue is one approach to preserve fertility for women who can be predicted to undergo premature ovarian failure as a consequence of chemotherapy, radiotherapy or genetic disorders. It is ...
Antimicrobial peptides and pathogenic Neissera : experimental studies in mouse, man and rat
(2005-08-19)
Antimicrobial peptides are important effector molecules of innate
immunity. In this thesis, the focus is on antimicrobial peptides of the
cathelicidin family, i.e. LL-37 in man, CRAMP in mouse and rCRAMP in rat.
Expression ...
Molecular diversity in the Notch receptor family
(2001-05-18)
We have studied the Notch family of transmembrane receptors, which play a crucial role in cell fate determination. The Notch signalling pathway represents a conserved mechanism to mediate signalling between adjacent, ...
Tumor-mediated changes in the immune system of cancer patients : a balancing act between suppressors and effectors
(2011-10-25)
Tumors and immune cells interact in many ways: immune cells can recognize and even kill tumor cells, while the tumor on the other hand can induce cells of the immune system to participate in tumor-mediated immune ...
Molecular studies on sex differences in hepatic gene expression and fuel metabolism
(2008-08-15)
In nature, sex difference is a multifactorial phenomenon. Although having a genotype of XX or XY determines the sex of an individual, the phenotypic sex differences are orchestrated by multiple factors such as developmental ...