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Regulation of dioxin receptor function by the Hsp90 chaperone complex
(2002-03-22)
In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental ...
Signaling via the bHLH-PAS proteins AhR and HIF
(2012-06-04)
This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a ...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as ...
Estrogen and aryl hydrocarbon receptor signaling
(2009-05-22)
The biological effects of estrogens are mediated by the two estrogen receptor (ER) isoforms, ERa and ERb. The ERs are ligand-inducible transcription factors that belong to the nuclear receptor (NR) superfamily. Ligand-activated ...
Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex
(2008-08-29)
The AhR belongs to the bHLH/PAS family of transcription factors, which
mediates biological effects of environmental pollutants such as
2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand
the AhR is ...
On GABAergic interneuron diversity and maturation
(2019-05-23)
GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what ...
Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model
(2003-02-13)
The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and ...
A tripartite of immune-, epithelial-, and nervous-systems in the homeostatic regulation of the gut
(2016-05-24)
Various cell types in the intestinal mucosa are constantly exposed to complex signals emanating from the lumen, including the microbiota and its metabolites. How these bilateral interactions in turn influences intestinal ...
Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli
(2010-03-26)
Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of ...