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Studies on astrocyte function : potential roles in brain water homeostasis and neuroprotection
(2012-10-23)
Astrocytes are essential in brain homeostasis and function, including maintenance of water and ion balance. Astrocytes express the water channel aquaporin 4 (AQP4), implicated in both physiological functions and injury ...
Bacteria and cancer : from toxin delivery to carcinogenesis
(2014-02-26)
Epidemiological evidence link certain chronic bacterial infections to a higher risk of cancer development. Induction of an inflammatory circuit and the accumulation of genomic instability are considered mechanisms by which ...
Insulin-like growth factor 1 receptor, novel functions and future possibilities
(2017-09-01)
Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces ...
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
(2005-08-19)
Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize ...
Ro52 antibodies and susceptibility genes in congenital heart block
(2007-08-31)
Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB
positive women. During pregnancy, the autoantibodies cross the placenta
and affect the fetus in which a potentially lethal atrioventricular (AV)
block ...
Molecular determinants of endocannabinoid-mediated brain development
(2017-03-10)
The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous ...
Cellular responses to the DNA damaging cytolethal distending toxin
(2009-09-25)
Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA ...
Workplace-based sick leave prevention and return to work : exploratory studies
(2011-05-27)
Background: Earlier research have revealed risk factors for sick leave in the workplace, and thus the workplace
has become an important arena for sick leave prevention and return to work (RTW). Despite that, some of these ...