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Importance of pharmacogenetic and environmental factors for variation in caffeine disposition : with special emphasis on CYP1A2, CYP2A6, NAT2 and XO
(2012-03-12)
Inter-individual variation in response to drugs conveys considerable risk of either therapy failure or drug toxicity. Caffeine, as one of the most frequently used psychoactive substances in the world, is not an exception, ...
Molecular pathogenesis of refractory anemia with ring sideroblasts (RARS) : role of the mitochondrial iron transporter gene ABCB7
(2011-08-18)
Refractory anemia with ring sideroblasts (RARS) is characterized by anemia, erythroid apoptosis, and mitochondrial ferritin (FTMT) accumulation. Granulocyte-colony-stimulating factor (G-CSF) inhibits some of these features ...
Fractures of the distal radius : epidemiology, treatment and outcome assessment
(2013-04-16)
This thesis aims to increase scientific knowledge of the most common fracture, namely the distal radius. Our understanding of this fracture is still limited, but every year in Sweden over 20,000 patients suffer from this ...
Mechanisms controlling midbrain dopaminergic neuron development
(2016-11-25)
The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated ...
Wrist fractures : aspects of surgical methods and outcome
(2014-05-23)
Wrist fractures are the most frequently occurring fractures in any emergency setting. Treatment
regimens range from a plaster cast to a combination of advanced surgical methods. Many fractures
heal without remaining ...
Local regulation of growth plate chondrocytes : molecular mechanisms and implications for longutidinal growth
(2010-10-08)
The regulation of linear growth is a complex and intriguing process that has the growth plate cartilage as its final target. Growth plate is a specialized cartilage localized in the end of the long bones between the ...
Interferon-beta treatment in multiple sclerosis : analysis of neutralizing antibodies
(2008-09-05)
Multiple sclerosis (MS) is a disabling chronic neurological disease with
a significant impact on patients lives. There is no cure for MS, but
recombinant interferon beta (IFN-beta) is currently the most established
disease ...
E-epidemiology : adapting epidemiological methods for the 21st century
(2009-08-28)
The traditional methods in epidemiological data collection are both costly and time consuming and less convenient for longitudinal large-scale studies. During the last decades, epidemiological studies suffer from low ...
Assessment of prognostic markers in benign and malignant melanocytic tumours
(2011-11-11)
Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past ...
Innate immunity in atherosclerosis : the role of pattern recognition receptors
(2014-10-15)
The pathogenesis of atherosclerosis is greatly influenced by the activities of both innate and adaptive immunity. Danger signals such as cholesterol crystals, oxidized LDL, and modified phospholipids may trigger sterile ...