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Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population
(2011-10-20)
Infectious diseases such as HIV, tuberculosis and malaria are endemic in Africa and often require concomitant treatments that may result into subsequent drug–drug interactions. Inter-individual variability in the ...
Neonatal complications following birth by vacuum extraction
(2017-10-25)
Background: Vacuum extraction is a common method of delivery presently accounting for approximately 7 percent of all deliveries in Sweden. It is considered an important and safe obstetric procedure, although both maternal ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...
Role of syndecan-1 in tumor cell proliferation and epithelial-mesenchymal plasticity
(2020-10-15)
Syndecan-1 (SDC1) is a heparan sulfate proteoglycan (HSPG) intercalated in the cell membrane but also translocated to the cell nucleus in a regulated manner. SDC1 is involved in several malignancy-associated processes such ...
Syndecan-1 insights in mesothelioma
(2017-10-30)
Syndecan-1 is a cell surface heparan sulfate proteoglycan expressing on epithelial cells. Heparan sulfate (HS) chains on syndecan-1 constitute growth factor attachment sites and facilitate growth factors to bind their ...
Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications
(2021-05-03)
Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple ...
Prostate cancer testing in Sweden : the interplay between cost and effectiveness
(2022-11-16)
As a major cause of male deaths in Sweden, prostate cancer constitutes an essential public health issue to the society. Early detection through an organised testing program with the prostate-specific antigen (PSA) test and ...