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Role of cytokines in experimental neurodegenerative and neuroinflammatory disorders
(2010-08-13)
Altered expression of cytokines in response to body injury has diverse actions that can exacerbate, mediate, reduce or inhibit neuronal and myelin damage as well as influence the disease development in a variety of nervous ...
Studies of mRNA transport and localization
(2011-05-17)
During mRNA biogenesis, a subset of newly exported mRNA is assembled into larger RNA granules which are transported to subcellular compartments for localized translation. These mechanisms are critical for asymmetric mRNA ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Studies on the reliability of biomarkers for alcohol use and abuse
(2013-01-10)
Alcohol is consumed by the vast majority of the population, but prolonged excessive drinking is associated with various negative health and social consequences. It is therefore important to identify individuals with at-risk ...
Exploring disease biomarkers and mechanisms using metabolomics
(2017-03-14)
A metabolome is the complete set of small molecules or metabolites present in a biological system. It is the result of internal, genetically determined processes, as well as external factors. The metabolome can consequently ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...
The next level : video gaming, cognition and motivation in surgical simulator training
(2015-05-08)
Image guided surgery uses small incisions or existing entry ports of the body in order to
decrease surgical trauma which will hopefully lead to less infections, complications and
number of days needed in the hospital. ...
Population structure and antibiotic resistance of the genus enterococcus in humans, animals and the environment
(2005-11-18)
Enterococci belong to the normal intestinal flora of humans and animals. An increased prevalence of antibiotic resistant enterococci causing nosocomial infections has drawn attention to the epidemiology and emergence of ...
Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption
(2005-11-18)
Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within ...
Leisure activities at old age and their influence on dementia development
(2009-04-20)
This thesis aims to describe the participation in leisure activities of elderly subjects and to detect their possible effect, if any, on the development of dementia. The data were derived from the Kungsholmen Project, which ...