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Leisure activities at old age and their influence on dementia development
(2009-04-20)
This thesis aims to describe the participation in leisure activities of elderly subjects and to detect their possible effect, if any, on the development of dementia. The data were derived from the Kungsholmen Project, which ...
Molecular regulators of glucose and lipid metabolism in skeletal muscle
(2012-04-27)
Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal ...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
(2006-04-07)
One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin ...
Insulin signalling and TBC1D1 in skeletal muscle metabolism
(2011-11-18)
Type 2 diabetes mellitus (T2DM) has taken the form of a pandemic disease globally as people adopt a more western lifestyle. High circulating glucose levels indicates that an individual is in the risk zone for developing ...
Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming
(2007-11-23)
Physical exercise enhances skeletal muscle responsiveness to insulin and
regulates metabolism by an insulin-independent mechanism. Elucidation of
contraction-mediated molecular mechanisms is imperative for a better
understanding ...
Novel pharmaceutical approaches to regulate glucose homeostasis
(2010-01-13)
The Western sedentary life-style and calorie excess is causing an increased incidence of obesity and type 2 diabetes. When untreated, these diseases are associated with heart- and vascular disease, stroke, cancer, neuropathic ...
Pathways controlling metabolic and hypertrophic responses in skeletal muscle
(2015-05-11)
Skeletal muscle displays an extensive capacity to adapt to a wide range of metabolic and mechanical stressors. As an insulin-sensitive and exercise-responding tissue, it plays a key role in the context of therapeutic ...
Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin
(2007-03-23)
Skeletal muscle fibers differ considerably in their metabolic and
physiological properties. The metabolic properties of skeletal muscle
display a high degree of flexibility which adapts to various
physiological demands ...
Central and peripheral mechanisms regulating energy and glucose homeostasis
(2013-05-23)
Obesity is a major health concern across the globe and is often associated with insulin resistance and type 2 diabetes. The coupling of ene rgy intake and expenditure is tightly regulated by central and peripheral mechanisms ...