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Studies on the regulation of leukotriene biosynthesis in antigen presenting cells
(2011-03-14)
Leukotrienes (LTs) are pro-inflammatory lipid mediators with important roles in host de- fense and inflammatory disease. Leukotriene B4 (LTB4) is a potent chemoattractant for neutrophils and contributes to bacterial killing, ...
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(2007-10-05)
The growth hormone (GH) / insulin-like growth factor (IGF) family of
ligands, binding proteins and receptors play multiple roles in cell
growth, metabolism and development. In addition, numerous studies have
demonstrated ...
Sudden unexpected death in epilepsy, incidence, circumstances and risk factors
(2020-02-12)
Although Sudden Unexpected Death in Epilepsy (SUDEP) has attracted increasing attention from the scientific community during the last 20 years, important gaps in knowledge still exist that hamper the development of methods ...
Genetic, cellular and clinical studies of hemophagocytic lymphohistiocytosis
(2012-09-21)
Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyperinflammatory condition characterized by fever, cytopenia, hepatosplenomegaly, and sometimes hemophagocytosis. HLH is typically divided into two distinct ...
Orofacial aspects of juvenile idiopathic arthritis in children
(2023-04-04)
Aims: This thesis, which investigates orofacial aspects and temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA), aims to improve knowledge about the variables to include in a clinical examination, ...
Sex hormones in gastric mucosal physiology and the development of oesophageal, gastric and colorectal adenocarcinoma
(2022-05-19)
The aim of this thesis was to continue to test the hypothesis that sex hormones play some part in the aetiology and seem to protect women from the development of oesophageal, gastric, and colorectal adenocarcinoma. All ...