Search
Now showing items 1-10 of 11
Molecular mechanisms of mammalian mitochondrial DNA replication and transcription
(2009-02-20)
Mitochondria are cytoplasmic organelles in eukaryotic cells, mainly devoted to the synthesis of ATP, through the Oxydative Phospshorylation System (OXPHOS). The organelle has its own genome, the mitochondrial DNA (mtDNA) ...
Epidemiological studies on socioeconomic inequalities and cardiovascular disease : prevention, progression and prognosis
(2020-02-20)
Cardiovascular disease (CVD) accounts for 30% of global mortality and is the most common cause of death in the world. Population-wide prevention strategies as well as healthcare interventions have led to a decrease in CVD ...
Regulation of striated muscle contraction
(2008-08-28)
Background and Aims: Muscle contraction involves cross-bridge interaction between actin and myosin filaments, which is regulated by variations of intracellular [Ca2+] and influenced by several external control systems. To ...
Identification of protein signatures of genomic stability/instability in epithelial cancers
(2011-11-17)
Aneuploidy is a consistent genetic alteration of the cancer genome. At early steps in the sequence of malignant transformation during human tumorigenesis, chromosomal aneuploidies can be the first detectable genetic ...
Colorectal cancer : genome, transcriptone and proteome dynamics
(2005-05-27)
Colorectal carcinomas are the third most common malignancies in the
Western World. Despite screening programs about 70% of these tumors are
detected at advanced stages. Late diagnosis, however, results in a
significant ...
Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis
(2022-12-21)
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. Two main reasons for this are that (Bacille Calmette–Guérin) BCG, the ...
Effects of physical training on physical performance in frail elderly people
(2007-10-12)
Aging is often accompanied by decreased muscle strength, aerobic capacity and balance, which can lead to impaired physical performance. Epidemiological data have demonstrated that low levels of physical activity are strongly ...
Cardiometabolic health in students and young adults with mild/moderate intellectual disabilities : results from a longitudinal follow-up study and a school intervention
(2013-01-28)
Background: Adults with intellectual disabilities (ID) develop the metabolic syndrome and cardiovascular disease more frequently than individuals without ID. The knowledge about cardiometabolic risk factors in adolescents ...
Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
(2013-09-12)
Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology ...
Parents who have lost a son or daughter through suicide : towards improved care and restored psychological health
(2013-12-19)
Background: Parents that have lost a son or daughter through suicide are at risk of developing psychological morbidity that may become long-lasting and even life-threatening. Despite this the aftermath of a suicidal loss ...