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Derivation, enrichment and characterization of dopaminergic neurons from pluripotent stem cells
(2010-04-06)
Parkinson s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons residing in the substantia nigra and innervating the straitum. Current medical interventions provide initial symptomatic ...
The role of interferon-regulated genes in the immune system
(2017-01-25)
Type I interferons (IFNs) are potent inducers of the first-line defense against pathogens. Their activity leads to the up- and downregulation of a large number of genes with various effects on the immune system, including ...
Gut derived chronic inflammation in HIV-1 and chronic kidney disease : the role of the microbial metabolite TMAO and immunomodulatory effects of Vitamin D
(2018-11-01)
Persistent immune activation with premature ageing and increased risk of cardiovascular disease (CVD) are features shared by HIV-1 infected individuals and patients with chronic kidney disease (CKD). Underlying dysbiosis, ...