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Clinical pharmacokinetics of intravenous ethanol : relationship between the ethanol space and total body water
(2001-10-26)
Introduction: Total body water (TBW) is an important parameter in
pathological states where the normal regulation of fluid balance is
impaired (e.g., during critical illness, congestive heart failure, bum
injury and ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Vaccine safety, vaccine effectiveness and other determinants for successful immunisation programmes
(2018-05-11)
The studies in this thesis examined several key determinants for successful uptake of vaccinations in the Nordic countries, with focus on vaccine safety and vaccine effectiveness. In study I, we investigated whether disease ...
New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11
(2010-12-14)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) ...
Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
(2007-09-07)
Osteoclasts are multinucleated bone-resorbing cells that have been
implicated in a variety of skeletal diseases e.g. osteoporosis,
rheumatoid arthritis and skeletal metastasis. Under physiological
conditions, the osteoclast ...
Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes
(2003-11-20)
Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these ...
Post-translational modifications of proteins in human breast cancer : proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis
(2011-11-11)
Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to ...
New treatment strategies for growth failure caused by chronic inflammation in children
(2012-12-21)
Chronic inflammation during childhood often leads to impaired bone growth and reduced height in adulthood. Interleukin-1β (IL-1β), interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) are pro-inflammatory cytokines ...
Local regulation of growth plate chondrocytes : molecular mechanisms and implications for longutidinal growth
(2010-10-08)
The regulation of linear growth is a complex and intriguing process that has the growth plate cartilage as its final target. Growth plate is a specialized cartilage localized in the end of the long bones between the ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
The human immune system, which protects the body from invading pathogens, largely depends on the proper function of lymphocytes, which are highly motile and constantly recirculate the blood and lymph. Adhesive and motile ...