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Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
(2003-05-23)
The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that is responsible for the activation of several response genes, of which the best characterised is the CYP1A1 gene. The prototype ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
The economic burden of mental health constitutes a substantial part of the total costs of illnesses. Most estimates of cost-of-illness focus on somatic illnesses and corresponding studies of mental health are few. In Sweden ...