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Molecular dynamic studies of nuclear receptors ligand binding domain
(2009-05-08)
Nuclear Receptors (NR) function as transcription factors that regulate
genes that affect processes like reproduction, development and
metabolism. The NRs are activated upon a given signal, which can be a
ligand binding ...
A study on the role of genes of innate immunity in type 1 diabetes
(2010-02-04)
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. ...
Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling
(2016-02-22)
Reversible reduction/oxidation (redox) reactions play key roles in cellular signaling pathways.
Particularly cysteine residues in proteins can be modified by reactive oxygen-, nitrogen- or sulfur
species (ROS, RNS, RSS), ...
A study of biomarker analysis in association with type 1 diabetes and their shared features in rheumatoid arthritis
(2014-10-03)
Type 1 diabetes (T1D) is mediated by abnormal immune system (autoimmunity) that targeting specifically to self insulin-producing cells (β-cells). People with T1D require treatments based on life-long insulin substitution. ...