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Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors
(2002-05-16)
Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells ...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
Introduction: Helicopter pilots complain of pain originating from the neck region. The causes are still basically unknown, but the ergonomic situation when flying a helicopter, with unfavorable load caused by static neck ...
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
(2008-09-05)
Nucleoside analogs are modified nucleosides used in treatment of cancer
and viral infections. They are dependent on intracellular phosphorylation
to be pharmacologically active. Deoxyribonucleoside kinases catalyze ...
Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase
(2008-10-17)
Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains ...
Unraveling genetic mechanisms in autism spectrum disorders
(2011-09-08)
Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders characterized by impairments in socialization and communication accompanied by repetitive and stereotypic behaviors. ASDs are highly heritable ...
Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases
(2006-09-15)
The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside ...
Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses
(2013-10-01)
Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is ...