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Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses
(2013-10-01)
Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is ...
Molecular mechanisms of transcriptional repression by the orphan receptor SHP
(2005-02-18)
SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate ...
Immune regulation during pulmonary TB and during M. tuberculosis/HIV-1 co-infection
(2013-09-04)
Individually, tuberculosis (TB) and acquired immunodeficiency syndrome (AIDS) pose major global health problems and together, they form a deadly liaison. Preventive vaccines for any of the diseases are not yet available. ...