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Structural enzymology of the biosynthesis of polyketide antibiotics
(2004-05-14)
Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, which makes them useful in treatment of various cancers. They are synthesised in the polyketide biosynthetic pathway as secondary ...
Epidemiological studies on frailty and its associations with mortality, dementia, and polypharmacy
(2023-01-12)
Frailty describes the status of decreased physiological reserves and increased vulnerability to adverse outcomes. As the aging population increases, frailty has become an important public health concern. However, longitudinal ...
Targeting MTHFD1 and MTHFD2 as cancer treatment
(2023-09-18)
One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and
therefore plays a central role in DNA replication and repair. To sustain rapid proliferation,
cancer cells often upregulate their 1C ...
Autoantibodies in congenital heart block
(2009-11-20)
Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. NLE is associated with several clinical manifestations including skin rash, cytopenia and congenital heart block (CHB). CHB is the ...
Dietary habits, commensal microbiome, and nasopharyngeal carcinoma
(2020-11-19)
Nasopharyngeal carcinoma (NPC) is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It has been widely accepted that the ...