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Skeletal muscle plasticity and energy metabolism
(2017-11-24)
Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, ...
SUMO and ubiquitin : the yin and yang of IGF-1R function
(2007-10-04)
Tumorigenesis is a multistep process involving genetic and epigenetic
alterations that drive the progressive transformation of normal human
cells into highly malignant derivatives. The insulin-like growth factor 1
receptor ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly
(2015-05-05)
AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse ...
CYP2C19 polymorphisms in drug metabolism and response
(2014-11-13)
Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience ...
Venous thromboembolism and mechanisms during assisted reproductive technology
(2020-11-20)
Background: Assisted reproductive technology (ART) is increasingly used worldwide to treat infertility
and assist couples and single mothers with their conception. The most common ART
procedure includes treatment with ...
Leadership development : a comparative evaluation of short-term and long-term programmes in Swedish health care
(2009-01-09)
Health care systems in Sweden and many other industrialised countries have undergone major technological, organisational, and financial changes during the last decades. Health care leaders and doctors are all key persons ...
Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 ...
Cell interactions in the CNS and their consequences for neuronal apoptosis
(2005-04-21)
The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury ...
Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : results from the OmegAD study
(2008-05-23)
Alzheimer's disease (AD) is a major public health concern in all
countries with an increasing prevalence. It is expected to quadruple by
the year 2047. AD is a progressive neurodegenerative disease with a
multifactorial ...