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Clinical and pathogenic aspects of otitis media
(2010-05-14)
One study on clinical treatment strategies in otitis media and two studies elucidating immunological events in otitis media in vitro, were conducted and joined in this thesis. First, topical treatment with or without ...
Influence of the microflora on gastrointestinal nitric oxide generation : studies in newborn infants and germ-free animals
(2006-05-11)
Interactions between intestinal bacteria and the host play an important role in physiological regulation of gut function and in development of various diseases. Nitric oxide (NO) exhibits a variety of biological actions ...
Structural and functional studies of proteins in cell signaling and cancer
(2014-11-20)
Cancer is one of the most common causes of death in the western world. Cancer is an umbrella term for over 100 different diseases all caused by mutations in cells leading to uncontrolled cell division and metastasis. The ...
Post-polio syndrome : physiotherapeutic analysis and interventions
(2013-01-24)
This thesis presents four studies focusing on outcomes of gait performance using gait analysis and/or the Six-minute-walk test (6MWT), in patients with post-polio syndrome (PPS). Further, resistance training in combination ...
Epigenetics in health and disease : on smoking, multiple sclerosis, and rheumatoid arthritis disease states
(2019-10-03)
The main aim of this thesis was to investigate the genome-wide DNA methylation in tissues associated with the immunopathogenesis of two autoimmune diseases, Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS), as well ...
The role of X-ray imaging and musculoskeletal ultrasound in the diagnosis and management of rheumatoid arthritis
(2014-10-31)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by symmetric joint inflammation that often involves the small joints of the hands and feet, with progressive destruction, deformity, and ...
HLA and KIR gene polymorphism in hematopoietic stem cell transplantation
(2006-09-01)
The major histocompatibility complex (MHC) in humans known as the Human Leukocyte Antigens (HLA) is localised to the short arm of chromosome six. The HLA class 1 antigens, HLA-A, -B and -C are highly polymorphic glycoproteins ...
The impact of health promotion on health in old age : results from community-based studies in rural Bangladesh
(2009-04-03)
Background: It is common knowledge that Bangladesh has a high prevalence
of illness among its older people and that the government healthcare
services offer them inadequate support. Despite this, however,
information ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Studies on the regulation and function of lipoxygenases in Hodgkin lymphoma
(2013-12-19)
Hodgkin lymphoma (HL) is a unique entity among the lymphomas, with a minority of malignant Hodgkin and Reed-Sternberg (H-RS) cells surrounded by a broad range of infiltrating cells. The infiltration of certain inflammatory ...