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Studies on the regulation and function of lipoxygenases in Hodgkin lymphoma
(2013-12-19)
Hodgkin lymphoma (HL) is a unique entity among the lymphomas, with a minority of malignant Hodgkin and Reed-Sternberg (H-RS) cells surrounded by a broad range of infiltrating cells. The infiltration of certain inflammatory ...
Hearing in menopausal women and in women with Turner syndrome : a model for hearing matured in an estrogen-deficient environment
(2009-04-03)
Epidemiological studies have shown that women have better high-frequency
hearing than men in virtually all age groups, regardless of
noise-exposure, and that agerelated hearing decline starts after age 30
in men but not ...
Novel treatment strategies and regulation of IgE-mediated allergic disease
(2008-02-15)
Allergic symptoms such as rhinoconjunctivitis, asthma or gastrointestinal
symptoms, triggered by inhaled or ingested allergens cross-linking
allergen-specific IgE on mast cells or basophils, are defined as
IgE-mediated ...
HIV-1 immune responses induced by natural infection or immunisation
(2009-05-21)
The development of an effective HIV-1 vaccine must be considered as one
of today s greatest biomedical goals and challenges. The nature of the
HIV-1 virus, characterised by its tropism for the CD4+ T cells of the
immune ...
Strategies to enhance the potency of HIV-1 DNA vaccines
(2011-11-10)
Despite 30 years of intense research on HIV/AIDS, we have yet to arrive at a prophylactic vaccine that confers complete protection. This mission is complicated by the virus’s vast genetic variability and its ability to ...
Depression and cognition in the elderly : neuroimaging perspective
(2017-05-03)
This thesis examines the relationship between depression and brain structure in the elderly with (Study I, III) and without (Study II, IV) cognitive impairment (Alzheimer’s disease and mild cognitive impairment). Individuals ...
Role of p21-activated kinase 4 in cell migration
(2010-11-30)
Cell migration is a cellular process that plays a critical role in various physiological and pathological phenomena, including in cancer metastasis. Understanding at a fundamental level how cancer cells migrate and invade ...