Search
Now showing items 1-8 of 8
Distal radius fractures : epidemiology and aspects of surgical management
(2020-11-06)
Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ...
Maternity care in Zambia : with special reference to social support
(2004-01-07)
The Zambian woman starts childbearing early and gives birth to an average
of 5.9 children during her reproductive period. The already high levels
of maternal deaths are increasing in Zambia. Only 43 per cent of the
women ...
Regulatory function of homeobox genes in the development of C. elegans
(2010-09-10)
The nematode worm Caenorhabditis elegans has been widely used as a genetic model for over 40 years to investigate developmental control genes. In this thesis, I studied the roles of several homeobox genes and a novel RNA ...
Bioinformatic methods in rare disease genomics
(2021-09-22)
The larger goal of medical genetics is to map genotype to phenotype and to understand how genomic variation affects human health. In the field of rare disease genomics, there is a mendelian assumption that states: one ...
Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation
(2001-09-14)
Leukotriene (LT) A4 hydrolase catalyzes the committed step in the
biosynthesis of LTB4, a classical chemoattractant and immuine-modulating
lipid mediator involved in inflammation, host-defense against infections,
and ...
Mechanism of enzymes involved in leukotriene C4 biosynthesis
(2016-09-06)
Cysteinyl leukotrienes (cys-LTs) are potent proinflammatory mediators associated with
various diseases including asthma and allergic rhinitis. Leukotriene C4 synthase (LTC4S) and
microsomal glutathione transferase 2 ...
Studies on coactosin-like protein interaction with 5-lipoxygenase
(2009-10-16)
Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase ...
Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases
(2007-01-01)
Leukotrienes (LTs) are a family of lipid mediators that are involved in
host defense and inflammatory responses. They are synthesized from
arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are
divided into ...