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Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications
(2007-08-17)
Uveal melanoma is the most common primary intraocular malignant tumor in
adults with 30% to 50% of patients that ultimately succumb to metastatic
disease, mainly to the liver. Although new diagnostic and therapeutic
tools ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...
Primary aldosteronism studies on screening, outcome of adrenalectomy and functional pathology
(2013-10-18)
This thesis comprises four studies with the general aim to improve the management of patients with primary aldosteronism (PA).
PA is a hypertensive disorder due to autonomous secretion of aldosterone from one or ...
Actin and myosin in transcription and chromatin regulation
(2016-05-02)
In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, involved in chromatin remodeling and histone modifications, and in different phases of gene transcription. Actin and myosin ...
The risk of type 1 diabetes in immigrants and their offspring in Sweden : the influence of perinatal factors
(2014-11-13)
Aims: The overall aim of this study was to investigate the trend in and risk factors for type 1 diabetes, with particular reference to parental socioeconomic position (SEP) and country of birth of subjects and their parents. ...
Pharmacokinetics and inner ear transport of cisplatin
(2015-02-25)
Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin
has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible
hearing loss. The ototoxic mechanisms of cisplatin ...
Eating habits among adolescents and their mothers : Stockholm Weight Development Study (SWEDES)
(2008-04-04)
The aims of this thesis were threefold. Firstly, to explore the possibility to improve the quality of dietary data and to identify under- and overreporters of energy intake. Secondly, to investigate the eating habits of ...
Mitochondria and cellular energy metabolism in platinum chemotherapy
(2009-09-18)
Chemotherapy is a major strategy in the treatment of cancer. Unfortunately, treatment of advanced cancers often fails due to tumor resistance to chemotherapeutic drugs. Studies of cell death signaling induced by chemotherapeutic ...
Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism
(2012-11-22)
Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone ...
The role of fibroblast growth factor 19 in human liver
(2020-05-04)
Bile acids are synthesized in the liver and are essential for intestinal absorption of lipids. Bile acid homeostasis is crucial and if not maintained, bile acids can accumulate to toxic levels and cause severe damage to ...