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AMP-activated protein kinase : the connection between exercise and type II diabetes
(2004-11-18)
Skeletal muscle insulin resistance is a hallmark feature of Type 2
diabetes. Physical exercise/muscle contraction elicits an
insulin-independent increase in glucose transport and perturbation of
this pathway can bypass ...
Mitochondrial dysfunction in ageing and degenerative disease
(2007-10-05)
The cytoplasm of eukaryotic cells contains a dynamic network of
double-membraned organelles, called mitochondria, which perform the
process of oxidative phosphorylation (OXPHOS) that provides cellular
energy in the form ...
Kinase cascades in the regulation of glucose homeostasis
(2005-03-09)
Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at
improving muscle insulin sensitivity by either directly modulating, or
bypassing defective insulin signaling. Insulin induces metabolic and ...
Health economic aspects of low back pain
(2019-01-11)
Four out of five people experience low back pain sometime during their lifetime. Problems of the back—and to a less extent of the neck—are consistently in the top seats among the most burdensome diseases in the developed ...
Molecular regulators of glucose and lipid metabolism in skeletal muscle
(2012-04-27)
Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal ...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
(2006-04-07)
One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin ...
Insulin signalling and TBC1D1 in skeletal muscle metabolism
(2011-11-18)
Type 2 diabetes mellitus (T2DM) has taken the form of a pandemic disease globally as people adopt a more western lifestyle. High circulating glucose levels indicates that an individual is in the risk zone for developing ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming
(2007-11-23)
Physical exercise enhances skeletal muscle responsiveness to insulin and
regulates metabolism by an insulin-independent mechanism. Elucidation of
contraction-mediated molecular mechanisms is imperative for a better
understanding ...