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Mechanisms of adaptation to the fitness cost of antibiotic resistance
(2007-05-18)
The dissemination and persistence of antibiotic resistance, is not only
depending on the volume of drugs used but also on the resistance
mechanisms effect of bacterial fitness (reproductive ability). Fitness is
a multifactorial ...
Factors influencing splanchnic microcirculation in animal models of endotoxaemia
(2011-04-20)
Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to ...
Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia
(2017-03-02)
Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
(2006-10-27)
Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ...
Dietary effects on gene regulation and function in human adipose tissue in obesity
(2007-05-04)
Obesity is an excess of body fat that develops from both genetic and environmental factors, leading to a disturbed balance between energy intake and energy expenditure. It is closely associated with insulin resistance, ...
Risk factors and outcomes in inflammatory myopathies
(2023-05-04)
Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available ...
Robot-assisted laparoscopy and sentinel node biopsy in high risk endometrial cancer
(2018-11-15)
Surgery is standard treatment for early stage endometrial cancer (EC), the most common gynaecological malignancy in developed countries. Traditionally, surgery has been performed by laparotomy (LT). Comprehensive surgical ...