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Pharmacokinetic consequences of CYP2D6 genotypes with emphasis on gene duplication / amplification
(2000-01-07)
The relationship between the major Caucasian and Oriental CYP2D6 genotypes and the disposition of two CYP2D6 substrates nortriptyline and debrisoquine was investigated.
Caucasians with 0, 1, 2, 3/4 and 13 functional ...
Sudden infant death syndrome : a medico-legal study of related cardiovascular, toxicological and genetic findings
(2002-05-03)
The present medico-legal investigation of the deaths of infants less than
one year of age was designed to enhance our understanding of the Sudden
Infant Death Syndrome (SIDS). Special emphasis was placed on the
significance ...
The impact of Bcl-2 family members on mast cell survival and apoptosis
(2008-10-31)
Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and ...
Molecular mechanisms of mammalian mitochondrial DNA replication and transcription
(2009-02-20)
Mitochondria are cytoplasmic organelles in eukaryotic cells, mainly devoted to the synthesis of ATP, through the Oxydative Phospshorylation System (OXPHOS). The organelle has its own genome, the mitochondrial DNA (mtDNA) ...
Somatostatin effects on the proteome of human prostate cancer cells
(2009-01-09)
The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer.
The aim of this thesis ...
Genetic predisposition and dietary factors in relation to adiponectin and insulin resistance
(2013-08-30)
Diabetes mellitus is a global health problem, owing to the high prevalence and enormous associated economic burden. Insulin resistance is a critical condition to the development of type 2 diabetes (T2D). Adiponectin, a ...
Studies on molecular regulation of inflammation in cutaneous lupus erythematosus
(2011-03-24)
Lupus erythematosus (LE) is an autoimmune disease with a wide range of clinical manifestations. This spectrum spans from limited cutaneous disease to life-threatening rheumatic disorder involving vital organs. Sun exposure ...
Tuberculosis in Stockholm : studies on transmission, prevention and control
(2013-05-08)
The first priority of tuberculosis control programs is diagnosis and treatment of all individuals with active tuberculosis. Contact tracing constitutes the second priority of tuberculosis prevention and control. Patients’ ...
Exosomes : the future of vaccination?
(2011-11-25)
Exosomes are small membrane vesicles that are secreted by cells as means of intercellular communication. They are typically between 50 and 100 nm in diameter and originate from the endosomal compartment of cells. Exosomes ...
Allergy to pets : molecular approaches for improved diagnostics and vaccination
(2012-05-25)
Allergic diseases are a major health problem, affecting up to 30% of the population in affluent countries. Domestic pets such as cats, dogs and horses are among the most common agents of IgE-mediated allergies. Conventional ...