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Identification of susceptibility genes for dyslexia
(2007-10-26)
Developmental dyslexia, also known as specific reading disability, is characterized by persistent difficulties in learning to read and spell in spite of adequate intelligence, education, social environment, and normal ...
Effects of alcohol consumption on health and mortality
(2001-01-26)
During the last 25 years, alcohol consumption has become a widely debated issue, especially due to research results, in which the beneficial effects of alcohol on health and mortality have been maintained. Research has ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
(2018-09-21)
Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current ...
Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets
(2020-02-18)
The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence ...
Nitric oxide in brain contusion
(2005-05-13)
Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain ...
Molecular diversity in the Notch receptor family
(2001-05-18)
We have studied the Notch family of transmembrane receptors, which play a crucial role in cell fate determination. The Notch signalling pathway represents a conserved mechanism to mediate signalling between adjacent, ...
Studies on the role of SOCS3 and STAT3 in development and function of the immune system
(2017-11-27)
The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...
Signal integration between notch and hypoxia : insights into development and disease
(2007-01-26)
Oxygen is essentially required for aerobic metabolism in most eukaryotic
organisms. Therefore, it is striking that a number of tissues develop,
and are maintained at low oxygen (hypoxic) conditions in the body. For
instance, ...
Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation
(2014-08-11)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens ...