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Nitric oxide and evaluation of different treatments in experimental colitis and inflammatory bowel disease
(2006-11-10)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder of unknown etiology of the gastrointestinal tract. Central features of IBD are increased ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Charcterization of biotransformation systems in human cells
(2007-05-25)
Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Understanding mechanisms of toxicity is an important part of improving safety assessment, ...
Traffic noise and cardiovascular disease
(2010-04-30)
Traffic noise is an increasing problem in urban areas worldwide, but health effects in relation to traffic noise exposure are not well understood. Several studies show that noise may give rise to acute stress reactions, ...
Immunological aspects of migration and tolerance
(2019-01-25)
The actions of the immune system are highly dependent on locality for development, memory imprinting, surveillance and effector functions. Migratory processes are therefore essential for maintaining immunological integrity ...
Clinical and genetic stratification of childhood psoriasis
(2015-04-29)
Psoriasis is a clinically heterogeneous and common disease affecting about 2-3% of the
population in Sweden. Twin and family studies have shown a strong and complex genetic
background in psoriasis. The strongest known ...
Protein expression in prostate cancer
(2006-01-06)
The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate ...
Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases
(2020-05-13)
Autoimmunity is caused by loss of tolerance, whereby the immune system fails to distinguish self from non-self. The autoimmune panorama entails more than 100 diseases that collectively affect close to 5% of the total ...
New insights on type 2 immunity key drivers : mast cells and group 2 innate lymphoid cells
(2019-02-22)
Type 2 immune responses are characterized by the production of cytokines IL-4, IL-5 and IL-13. They are known to have crucial physiological and pathophysiological functions in the body. Data from recent studies indicate ...