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Self-reported fecal incontinence and quality of life among gynecological cancer survivors
(2010-05-07)
Gastrointestinal symptoms following pelvic radiotherapy are common;
however, selfreported descriptions of gastrointestinal symptoms and their
impact on daily life among gynecological cancer survivors are rare in ...
Oral health in patients with chronic kidney disease
(2009-11-13)
Chronic kidney disease (CKD) is a complex disorder in which active intervention leads to longer survival expectancy. Oral diseases are complex disorders caused mainly by bacterial, fungal, or viral infections, where primary ...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
Studies on sterol 27-hydroxylase (CYP27A1)
(2004-01-30)
Human sterol 27-hydroxylase (CYP27A1) has been studied in the present thesis with focus on substrate specificity and possible role of the enzyme for prevention of accumulation of cholesterol and cholestanol in tissues. ...
Side-chain oxidized oxysterols as metabolic regulators in liver and brain
(2014-02-03)
Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half-life and their ability to pass lipophilic membranes easily, thus they are considered as important intermediates in cholesterol excretion ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(2010-03-26)
Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and ...
Estrogen and liver X receptors in human disease
(2006-11-10)
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...