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Dopamine D2 receptor G protein coupling and it's regulation
(2004-01-08)
Dopamine (DA) receptors belong to the superfamily of G protein coupled
receptors. The D2 DA receptor is negatively coupled with adenylate
cyclase via pertussis toxin sensitive (Gi/o) G proteins. In the brain the
D2 DA ...
The face of wrath : how facial emotion captures visual attention
(2003-05-23)
We look at the things that matter to us. We may rest our eyes on things that attract us, stare at something horrifying, or glare at someone we dislike: things that affect us emotionally are also things that capture our ...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Menstrual status and long-term cardiovascular effects of intense exercise in top elite athlete women
(2008-03-28)
Although physical exercise is generally beneficial for health, female athletes run an elevated risk of developing chronic energy deficiency, with ensuing severe consequences such as reproductive dysfunction, bone ...
p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
(2001-11-09)
The astrocytic gliomas are the most common form of brain tumors in
humans. The malignant progression from low grade (astrocytoma, grade II)
to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well
documented ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
Prior knowledge and present events in the brain
(2005-08-05)
Our experience the world is dependent on both the surroundings and the brain. In other words, perception is a synthesis of incoming signals, internal state, and previous knowledge rather than a mere reflection of the ...
Interference control in working memory : neurobehavioral properties and age differences
(2018-11-08)
This doctoral thesis aimed to investigate the basic processes of interference control (IC) in working memory (WM). We sought to unravel some of the underlying mechanisms of IC by examining brain correlates, while also ...
Exploring the therapeutic effects of p53 modulation in cancer and immune cell biology
(2023-04-26)
The tumor suppressor protein p53 is dysregulated in almost all cancer. In around 50% of cancer p53 retains wild type activity but its inactivation by the E3 ligase MDM2 in a heterodimer complex with MDMX may be amplified, ...
Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
(2023-03-09)
A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. Tumor suppressor ...