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Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress
(2010-03-05)
Cancer is the second leading cause of death in privileged countries. Tremendous efforts have been done to improve the efficiency of cancer treatment. Anti-cancer drug resistance is still a major problem in failure of cancer ...
Environmental factors and risk of acoustic neuroma
(2014-05-19)
The aim of this thesis was to increase the knowledge about environmental risk factors of acoustic neuroma and to increase the understanding of the methodological problems encountered when studying this tumor.
Acoustic ...
Environmental factors and p53 mutation spectrum in lung cancer
(2006-05-19)
The use of molecular biomarkers, such as mutations in the p53 gene, has raised expectations for improving the resolution power in epidemiological studies. In this thesis we assessed the influence of smoking, environmental ...
Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(2020-06-17)
In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) constitute ...
Outcome in patients with trochanteric and subtrochanteric femoral fractures : aspects on surgical methods, quality of life and cognitive function
(2011-11-11)
A hip fracture is a significant cause of increased morbidity and mortality in elderly people and Scandinavia presents the highest incidence of hip fractures worldwide. The hip fracture is a serious consequence of osteoporosis ...