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Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
(2017-01-16)
Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between ...
Hamstring muscle strain
(2008-04-25)
Background: Acute hamstring strains are common injuries in different sports. They are often serious, causing long rehabilitation times and a proneness for re-injury. Preliminary observations indicate that the injuries can ...
Artificial intelligence in histopathology image analysis for cancer precision medicine
(2023-09-29)
In recent years, there have been rapid advancements in the field of computational
pathology. This has been enabled through the adoption of digital pathology
workflows that generate digital images of histopathological ...
Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness
(2020-09-10)
Breast cancer is a heterogeneous disease. Aggressive subtypes are characterized by faster growth rates, increased capability to invade and metastasize, leading to poorer clinical outcomes. In this thesis, we use a molecular ...
Colorectal cancer : genome, transcriptone and proteome dynamics
(2005-05-27)
Colorectal carcinomas are the third most common malignancies in the
Western World. Despite screening programs about 70% of these tumors are
detected at advanced stages. Late diagnosis, however, results in a
significant ...
Artificial intelligence for breast cancer precision pathology
(2022-11-09)
Breast cancer is the most common cancer type in women globally but is associated with a continuous decline in mortality rates. The improved prognosis can be partially attributed to effective treatments developed for subgroups ...
Decoding the contribution of transcription factors to cell fate determination
(2018-11-19)
It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ...
Improving biomarker assessment in breast pathology
(2020-09-02)
The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice ...
Biological and therapeutic aspects of breast cancer progression
(2017-05-11)
Breast cancer is the second leading cause of cancer related death in women worldwide1. Although majority of primary breast cancers are curable with current treatment strategies, treatment outcome of metastatic breast cancer ...