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Coordination of endocytosis at the synaptic periactive zone
(2006-03-03)
Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To ...
Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses
(2013-10-01)
Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is ...
Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea
(2012-10-30)
Cells in the mammalian hearing organ, the cochlea, develop a specialized patterning and cellular architecture necessary for hearing function. Cytoskeletal components, such as actin and microtubules, maintain the material ...
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(2021-02-15)
The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
Register-based studies of hypospadias
(2017-05-19)
Hypospadias is a common genital malformation ofcomplex origin. It is characterized by misplacement of the urethral orifice, proximal to the tip of the glans penis, and is most often accompanied by a cleaved prepuce and ...
Prognostic and biological implications of epigenetic changes in leukemia
(2011-12-23)
The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce.
We conducted two retrospective studies in AML. The ...