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Alzheimer disease : studies on Abeta and gamma-secretase in human brain
(2010-01-15)
Alzheimer disease (AD) is a devastating neurodegenerative disorder and
the most prevalent form of dementia. One hallmark of the disease is the
extracellular deposition of amyloid beta-peptide (Abeta) into senile
plaques ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal ...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
CD8alpha/alpha+ T-cells and immune memory
(2009-04-29)
A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered ...
Child health problems and use of health services in a rural district in Vietnam
(2011-11-28)
Background: Like many other low and middle income countries, Vietnam has experienced a period of social, economic and epidemiological transition. The health care system has undergone considerable changes, and it is important ...
The effect of chronic alcoholism on epigenetic patterns regulating gene expression and neurodegeneration in the human brain
(2007-01-12)
Chronic alcoholism causes about 3.2% of all deaths worldwide. It has an
association to about 60 different diseases and injuries with enormous
social and economical impact. Despite these facts, very few
pharmacological ...
Single cell studies of human T cell function with applications for HIV-1
(2016-04-18)
T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, ...
A study of the transition from premalignancy to clinical prostate cancer
(2005-09-16)
Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation ...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
Influence of oxidative stress on aryl hydrocarbon receptor signaling
(2013-05-13)
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The ...