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Nitrite ion : its role in vasoregulation and host defenses
(2005-11-25)
Nitrite and nitrate are distributed throughout the human body, with especially high levels being present in saliva. Until recently, these anions were considered merely to be inert end-products of the oxidation of endogenous ...
Identification of the adult septic patient in the prehospital and emergency department setting
(2019-05-22)
Sepsis is one of the most urgent conditions encountered within emergency care but is often difficult to recognize due to its non-specific presentations. One third of the patients lack the classic sign of infection; i.e. ...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like ...
Molecular genetic studies on cerebrospinal fluid monoamine metabolites in psychotic patients and healthy individuals
(2015-02-26)
Dopamine, serotonin and noradrenaline are the major monoamines in the human central nervous system (CNS) and following their basic pathways they are degraded to their major metabolites homovanillic acid (HVA), 5-hydroxyi ...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins ...
Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population
(2003-11-21)
The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant ...
Development of a recombinant protein vaccine against Plasmodium falciparum malaria
(2006-05-26)
Malaria, caused by Plasmodium falciparum is one of the world´s deadliest diseases, killing one to two million children, while another 500 million suffer from clinical attacks every year. Infections caused by P. falciparum ...
Improved diagnosis and management of sepsis and bloodstream infection
(2022-11-08)
Sepsis is a severe organ dysfunction triggered by infections, and a leading cause of hospitalization and death. Concurrent bloodstream infection (BSI) is common and around one third of sepsis patients have positive blood ...
Surface antigens and virulence in Plasmodium falciparum malaria
(2008-11-21)
Plasmodium falciparum is an intracellular protozoan that may cause severe forms of malaria. It is a major world health hazard and reaps the highest toll among the children and pregnant mothers of the developing world. An ...
Cellular immune responses to low density lipoprotein in atherosclerosis
(2010-05-21)
Atherosclerosis is an inflammatory disease of the medium and large sized arterial vessels. Low density lipoprotein (LDL) particles carrying cholesterol are trapped within the arterial intima and elicit both innate as well ...