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Dendritic cells in immune and gene therapy against cancer
(2003-01-10)
Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid ...
Ligand binding and mechanism of microsomal glutathione transferase 1
(2009-01-09)
The homo-trimeric, membrane bound Microsomal Glutathione Transferase 1 (MGST1, EC. 2.5.1.18) belongs functionally to both the glutathione transferase family (GST) and the Membrane Associated Proteins in Eicosanoid and ...
Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy
(2020-01-23)
BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic ...