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Adolescents' encounters with public space : safety and mobility in relation to individual and contextual factors in Sweden
(2011-01-14)
) in Stockholm County, Sweden; and the WHO survey Health Behaviour in School-aged Children (HBSC) among a nationally representative sample of 5th, 7th and 9th graders in Sweden (n= 4144). The surveys included some identical or similar questions. In 2008/09, ten...
Computed tomography based assessment of treatment response in solid tumors
(2012-08-28)
than four target lesions might cause discrepancies when more than five target lesions were present (study I). Interobserver variation using RECIST and WHO-criteria were moderate: 0.53 (95%CI 0.33 - 0.72) and 0.60 (0.39 – 0.80), respectively...
CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(2010-12-23)
Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ...
Steroid metabolism in human reproductive organs
(2011-01-27)
showed significantly higher transcriptional activity of the G variant in Hek293 cells (2.7-fold ) The allele frequency was 4.04% in Swedes and 0.33% among Koreans. No association to prostate cancer could be found when tested in the previously described...
Assessment of 3D movements in the lumbar and cervical spine with a new CT based method
(2011-10-28)
subjects was 2.8 degrees in rotation and 1.8 mm in translation in vertebral segment. The mean facet joint 3D movement was for the right 6.1 mm and for the left 6.9 mm in L4-L5 segment and for the L5-S1 segment for the right facet 4.5 mm and 4.8 mm...
Spatial control of postsynaptic proteins : a role in brain plasticity
(2012-11-26)
, to elucidate whether GPCRs share a common mode of transport. We show that the 5-HT1B receptor, in contrast to other GPCRs, is transported in vesicles in the lumen of the dendrites. We show that the vesicles release the receptors to the membrane close...
Cardiac rehabilitation in women
(2012-01-11)
The overall aim of this thesis has been to investigate the prognostic value of exercise capacity and whether a multifactorial rehabilitation program could affect traditional cardiac risk factors as well as self-rated health, ...
Inflammatory markers for evaluation of inflammatory bowel disease therapy
(2011-05-06)
The lack of reliable biomarkers for predicting the clinical course or monitoring therapeutic outcome in inflammatory bowel disease is an indisputable problem. The aim of this study was to evaluate markers of inflammation ...
Improved scientific basis for human health risk assessment factors by toxicokinetic population modeling
(2013-08-12)
parameters. The influence of age and gender on the internal dose was slight. Thus, the factors obtained for all substances were below 2.5. However, the effects of fluctuations in exposure level and workload increased the CSAFHK up to 6.1, indicating...
Cardiovascular aspects in mild primary hyperparathyroidism and the outcome after parathyroidectomy
(2011-05-05)
Data on the extent and clinical significance of cardiovascular abnormalities in primary hyperparathyroidism (PHPT) are conflicting. The main objective of this thesis was to evaluate the cardiovascular function in patients ...