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CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(2010-12-23)
Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ...
Mitochondrial DNA mutations : brain developmental and ageing consequences, and possible treatments
(2012-09-06)
the appearance of overt ageing phenotypes. The lactate dehydrogenase (LDH) genes responsible for the interconversion of pyruvate-to-lactate, LDH-A and LDH-B, which generate the H and M subunits of the 5 different tetrameric LDH isoenzymes, were analyzed...
Adolescents' encounters with public space : safety and mobility in relation to individual and contextual factors in Sweden
(2011-01-14)
) in Stockholm County, Sweden; and the WHO survey Health Behaviour in School-aged Children (HBSC) among a nationally representative sample of 5th, 7th and 9th graders in Sweden (n= 4144). The surveys included some identical or similar questions. In 2008/09, ten...
The clinical use of genetic analyses in colorectal cancer
(2011-11-22)
biopsy and the occurrence of K-ras mutations, methylation of p16 and MGMT, and loss of heterozygosity (LOH) at 5q, 17p and 18q were analysed. We found that the distribution of methylated p16 and MGMT and LOH at 5q, 17 p and 18q are heterogeneous...
Characterizing life-long human exposure to persistent environmental pollutants
(2011-11-18)
/day) compared to the lowest (median 98 ng/day) using a Cox regression model. Highly exposed individuals were characterized by a high fish consumption independent of age. A high dietary PCB153 exposure and a low intake of fish fatty acids (<0.20 g/day of EPA...
Attention-deficit/hyperactivity disorder and disruptive behavior disorders in adolescence related to levels of platelet MAO-B and polymorphisms in two candidate genes
(2011-09-14)
. Several of their symptoms, have been linked to genotypes (e.g. monoamine oxidase A Variable Number of Tandem Repeats (MAO-A VNTR) and the 5–HydroxyTryptamine Transporter gene-Linked Polymorphic Region (5-HTT LPR)) as well as to platelet Monoamine oxidase B...
Spatial control of postsynaptic proteins : a role in brain plasticity
(2012-11-26)
, to elucidate whether GPCRs share a common mode of transport. We show that the 5-HT1B receptor, in contrast to other GPCRs, is transported in vesicles in the lumen of the dendrites. We show that the vesicles release the receptors to the membrane close...
Treatment of displaced proximal humeral fractures in elderly patients
(2011-05-06)
humeral fracture were included in a study with the aim to evaluate the responsiveness of the EQ-5D instrument. The EQ-5D displayed good internal and external responsiveness and can be recommended for use as a quality-of-life measure in patients...
Nitric oxide formation from inorganic nitrate and nitrate : contribution from eukaryotic and prokaryotic pathways
(2011-10-19)
Nitric oxide (NO) is an essential signaling molecule that plays a central role in a broad range of physiological functions. Classically, NO is synthesized from L-arginine and molecular oxygen by NO synthases. Once formed, ...
A community-based child drowning prevention program in Bangladesh : a model for low income countries
(2010-11-25)
Background: Drowning is a global public health problem of children. Children of low- and
middle-income countries are the most susceptible victims. Prevention measures implemented in
high-income countries have effectively ...